Studies on the dynamics of pepsinogen distribution.

Distribution of materials (such as enzymes) between the alimentary canal and the blood stream is a complex process involving the factors of synthesis, movement into one or more compartments, and destruction.' An initial attempt to quantitate these events is presented. A theory and methodology are developed and illustrated by preliminary data on the distribution of pepsinogen. The general approach shown here (measuring the material in the blood stream and in the parent organ, and again in the vascular pool after removal of the organ) also has applications in following the kinetics of blood-borne substances of extra alimentary origin.